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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DKC1 All Species: 11.21
Human Site: S451 Identified Species: 17.62
UniProt: O60832 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60832 NP_001354.1 514 57674 S451 T A K R K R E S E S E S D E T
Chimpanzee Pan troglodytes XP_521345 595 65925 S532 T A K R K R E S E S E S D E T
Rhesus Macaque Macaca mulatta XP_001090867 597 66468 S534 T A K R K R E S E S E S D E T
Dog Lupus familis XP_549382 517 57997 P455 A A E V V K A P K R K R D S E
Cat Felis silvestris
Mouse Mus musculus Q9ESX5 509 57483 R447 E A V N V I K R K R D S E S E
Rat Rattus norvegicus P40615 509 56597 V446 T A D A A S I V K R K R D S D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514686 519 58453 E457 E S G S E S D E A A P S S P V
Chicken Gallus gallus Q5ZJH9 516 58132 V452 S E S E N E A V S P P P S P A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001028279 506 56658 A443 S E G E A A A A A Q D T S K T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O44081 508 56812 T443 P S K R K L S T S S V E E T A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O17919 445 50192 G384 K K Q M V K D G L L D K F G K
Sea Urchin Strong. purpuratus XP_001187533 541 60439 A472 K K D K K A K A E A V E E E E
Poplar Tree Populus trichocarpa XP_002323264 482 54054 E421 A G L A A A A E P V K K K K S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LD90 565 63008 K501 S E K K E K K K K K D K K E E
Baker's Yeast Sacchar. cerevisiae P33322 483 54686 E414 E E P K K A K E D S L I K E V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.3 85.5 89.9 N.A. 90 83.2 N.A. 85.3 81.4 N.A. 74.7 N.A. 64.7 N.A. 58.7 64.8
Protein Similarity: 100 85.3 86 93.6 N.A. 93.1 90.8 N.A. 88.8 89.9 N.A. 85.4 N.A. 77.6 N.A. 71.4 77
P-Site Identity: 100 100 100 13.3 N.A. 13.3 20 N.A. 6.6 0 N.A. 6.6 N.A. 26.6 N.A. 0 20
P-Site Similarity: 100 100 100 40 N.A. 40 33.3 N.A. 33.3 6.6 N.A. 40 N.A. 46.6 N.A. 26.6 53.3
Percent
Protein Identity: 61.2 N.A. N.A. 57.5 57.9 N.A.
Protein Similarity: 76.4 N.A. N.A. 73.4 71.9 N.A.
P-Site Identity: 0 N.A. N.A. 13.3 20 N.A.
P-Site Similarity: 20 N.A. N.A. 60 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 40 0 14 20 27 27 14 14 14 0 0 0 0 14 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 14 0 0 0 14 0 7 0 27 0 34 0 7 % D
% Glu: 20 27 7 14 14 7 20 20 27 0 20 14 20 40 27 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % F
% Gly: 0 7 14 0 0 0 0 7 0 0 0 0 0 7 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 7 7 0 0 0 0 7 0 0 0 % I
% Lys: 14 14 34 20 40 20 27 7 27 7 20 20 20 14 7 % K
% Leu: 0 0 7 0 0 7 0 0 7 7 7 0 0 0 0 % L
% Met: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 7 7 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 7 0 7 0 0 0 0 7 7 7 14 7 0 14 0 % P
% Gln: 0 0 7 0 0 0 0 0 0 7 0 0 0 0 0 % Q
% Arg: 0 0 0 27 0 20 0 7 0 20 0 14 0 0 0 % R
% Ser: 20 14 7 7 0 14 7 20 14 34 0 34 20 20 7 % S
% Thr: 27 0 0 0 0 0 0 7 0 0 0 7 0 7 27 % T
% Val: 0 0 7 7 20 0 0 14 0 7 14 0 0 0 14 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _